John H Zhang Selected Research

Glycoproteins (Glycoprotein)

1/2023	Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage.
1/2018	Osteopontin attenuates inflammation via JAK2/STAT1 pathway in hyperglycemic rats after intracerebral hemorrhage.
7/2017	Intranasal administration of vitamin D attenuates blood-brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44/P-gp glycosylation signaling after subarachnoid hemorrhage in rats.
10/2014	Follistatin-like 1 attenuates apoptosis via disco-interacting protein 2 homolog A/Akt pathway after middle cerebral artery occlusion in rats.
1/2011	Effect of recombinant osteopontin on cerebral vasospasm after subarachnoid hemorrhage in rats.
2/2010	Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats.

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John H Zhang Research Topics

Disease

187	Brain Injuries (Brain Injury) 12/2023 - 09/2002
134	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 05/2024 - 02/2002
118	Brain Edema (Cerebral Edema) 12/2023 - 08/2004
71	Hypoxia (Hypoxemia) 01/2022 - 09/2002
64	Inflammation (Inflammations) 03/2024 - 07/2005
64	Cerebral Hemorrhage 03/2024 - 05/2004
64	Ischemia 01/2021 - 02/2002
62	Hemorrhage 01/2024 - 02/2002
60	Stroke (Strokes) 02/2024 - 05/2004
52	Infarction (Infarctions) 12/2023 - 02/2002
51	Neuroinflammatory Diseases 03/2024 - 04/2010
45	Brain Ischemia (Cerebral Ischemia) 01/2024 - 02/2002
45	Ischemic Stroke 08/2023 - 09/2003
33	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2024 - 07/2006
25	Hematoma 02/2023 - 05/2004
23	Wounds and Injuries (Trauma) 01/2020 - 07/2005
22	Intracranial Vasospasm 01/2019 - 02/2002
19	Brain Infarction 12/2023 - 07/2003
17	Edema (Dropsy) 12/2020 - 04/2005
13	Hydrocephalus (Hydrocephaly) 02/2022 - 01/2011
13	Atrophy 01/2021 - 11/2009
11	Hyperglycemia 10/2021 - 03/2007
11	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2020 - 06/2011
11	Body Weight (Weight, Body) 10/2016 - 03/2007
10	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 05/2020 - 02/2010
9	Neurologic Manifestations (Neurological Manifestations) 10/2020 - 07/2003
9	Reperfusion Injury 02/2019 - 05/2004
7	Hemorrhagic Stroke 01/2018 - 03/2010
6	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 04/2010
6	Neoplasms (Cancer) 08/2019 - 01/2005
5	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2017 - 05/2008
4	Herpes Zoster 01/2024 - 12/2009
4	Encephalitis (Encephalitis, Rasmussen) 08/2023 - 02/2014
4	Thrombosis (Thrombus) 01/2023 - 07/2002

Drug/Important Bio-Agent (IBA)

63	Oxygen (Dioxygen)IBA 01/2018 - 02/2002
51	Proteins (Proteins, Gene)FDA Link 02/2024 - 02/2002
39	Neuroprotective AgentsIBA 01/2024 - 07/2006
38	salicylhydroxamic acid (SHAM)IBA 01/2019 - 09/2003
31	Small Interfering RNA (siRNA)IBA 10/2023 - 03/2009
26	Caspase 3 (Caspase-3)IBA 01/2021 - 07/2003
22	HydrogenIBA 01/2021 - 08/2008
21	CytokinesIBA 11/2023 - 11/2003
20	OsteopontinIBA 03/2024 - 02/2010
19	Hemoglobins (Hemoglobin)IBA 01/2024 - 02/2011
17	Collagenases (Collagenase)FDA Link 01/2024 - 10/2004
13	fluoro-jade CIBA 12/2023 - 03/2016
13	Therapeutic UsesIBA 01/2023 - 03/2002
13	Matrix Metalloproteinases (MMPs)IBA 01/2021 - 07/2006
13	Evans Blue (Blue, Evans)FDA Link 07/2017 - 07/2006
12	Isoflurane FDA LinkGeneric 10/2020 - 07/2010
12	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 03/2007
12	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2016 - 08/2004
12	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 10/2015 - 01/2007
11	AntioxidantsIBA 01/2024 - 01/2008
11	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2021 - 10/2004
10	Phosphotransferases (Kinase)IBA 01/2019 - 02/2011
9	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021 - 05/2004
9	Anesthetics (Anesthetic Agents)IBA 10/2020 - 03/2009
9	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2016 - 02/2002
9	Messenger RNA (mRNA)IBA 01/2012 - 02/2002
8	InflammasomesIBA 03/2024 - 10/2013
8	Tight Junction ProteinsIBA 01/2024 - 11/2009
8	Sirtuin 1IBA 10/2021 - 02/2015
8	CateninsIBA 09/2021 - 04/2012
8	Peroxidase (Myeloperoxidase)IBA 01/2018 - 06/2008
7	Interleukin-6 (Interleukin 6)IBA 03/2024 - 11/2003
7	Protein Kinases (Protein Kinase)IBA 01/2021 - 08/2004
7	Thrombin FDA Link 01/2021 - 04/2009
7	IntegrinsIBA 01/2021 - 11/2010
7	Erythropoietin FDA Link 01/2015 - 02/2004
7	hydrogen rich salineIBA 04/2011 - 04/2009
6	Glycoproteins (Glycoprotein)IBA 01/2023 - 02/2010
6	Adenosine Triphosphate (ATP)IBA 12/2021 - 07/2002
6	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 03/2021 - 07/2003
6	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2017 - 02/2002
6	Mitogen-Activated Protein KinasesIBA 01/2016 - 03/2002
6	Free RadicalsIBA 01/2016 - 04/2005
6	MelatoninIBA 01/2011 - 01/2008
6	NADPH Oxidases (NAD(P)H oxidase)IBA 08/2007 - 02/2004
5	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2023 - 10/2019
5	TOR Serine-Threonine KinasesIBA 08/2023 - 07/2012
5	Biomarkers (Surrogate Marker)IBA 08/2023 - 01/2018
5	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2023 - 01/2018
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2023 - 11/2003
5	EnzymesIBA 01/2023 - 05/2008
5	Immunoglobulin G (IgG)IBA 01/2021 - 04/2008
5	Adenosine Monophosphate (AMP)IBA 10/2020 - 04/2017
5	Malondialdehyde (Propanedial)IBA 01/2020 - 03/2009
5	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2018 - 01/2011
5	Fingolimod Hydrochloride (FTY720)FDA Link 01/2017 - 02/2010
5	Coloring Agents (Dyes)IBA 01/2016 - 02/2011
5	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA 06/2015 - 09/2009
4	Cathepsin BIBA 03/2024 - 07/2006

Therapy/Procedure

68	Therapeutics 01/2023 - 03/2002
41	Ligation 01/2022 - 09/2002
19	Hyperbaric Oxygenation 01/2018 - 09/2002
13	Intranasal Administration 12/2023 - 11/2013
13	Neurosurgical Procedures 01/2020 - 03/2007
9	Electrocoagulation (Electrocautery) 01/2019 - 01/2007
5	Sutures (Suture) 01/2016 - 07/2006